Clinical Studies

Bio DNA Cellular Complex


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BioDNA Cellular Marine Complex (highly polymerized) is a marine substance that is well absorbed and perfectly tolerated in strong doses.It is a strong antioxidant, hydro soluble membrane protector and a radiation protective substance. It is effective in the treatment of asthenia (loss of strength and energy), arthrosis (inflammatory joint pain) and periodontal pathology. Further it permits the amelioration of physical and intellectual performance, cicatrisation (healing of) and the performance of the immune system.
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Summary of Clinical Studies for BioDNA Cellular Marine Complex

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Effective For Healing
It possesses cicatrisation (healing of), notably in the case of immune depression or in the course of infectious pathologies. Its administration permits general restoration and the treatment of the physical effects of asthenia (loss of strength and energy).

Reduce Undesirable Symptoms Of
Radiation And Chemotherapy For Cancer Patients
Its anti-oxidant activities have been effective against the harmful effects of ionizing radiation. It can be, in cancerology, a post cure administered to reduce the undesirable effects of radiation therapy.
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Effective For Inflammatory Joint Pain
Finally, its efficacy on essential arthralgies (joint pain) and its chondro stimulant properties are possibly associated with its cartilage extract which is rich in glucosamine and/or chondroitin, and effective as a therapy for arthrose (inflammatory joint pain).

Effective For Professional Sports’ Athletes Performance
In athletes its interest resides particularly in its help in physical performance. Especially in elevating the VO2 maximum and reducing the recuperation time.
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BioDNA Cellular Marine Complex
Clinical Studies

Clinical Study 1: Celergen BioDNA Cellular Marine Complex Is Effective In Treating Basic Arthralgies (Joint Pain)
In a double blind, multicentric clinical study, 116 patients suffering from chronic spinal problems (for a period of more than 1 month), the effect of only BioDNA Cellular Marine Complex (1g/day for 40 days) was evaluated against a placebo.

The intensity of the pain, quantified on the numeric scale of Huskinson diminished by 43.6% with BioDNA Cellular Marine Complex (versus 25.4% with placebo).

The degree of functional discomfort regressed by 32.7% with BioDNA Cellular Marine Complex (versus 25.5% with placebo).

The importance of the limitation of passive mobilization of the spine observed a drop of 43.3% with BioDNA Cellular Marine Complex (versus 26.9% with placebo).
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Clinical Study 2a: Celergen BioDNA Cellular Marine Complex Is Effective For Osteoarthritis
In an open study, 2960 persons affected by arthrosis (inflammatory joint pain) with an average age of 61 years old, received for 1 or 2 months an association of BioDNA Cellular Marine Complex (200mg/day) and a complex of vitamins B and E.

Benefits from this treatment were seen at the end of the 1st month of treatment. Much of the pain associated with arthrosis (inflammatory joint pain) was relieved in 89.5% of the cases (21% relieved completely, and 68.5% were partially relieved).

Physical performance was improved in 83.6% of the cases.

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Clinical Study 2b:
Celergen BioDNA Cellular Marine Complex VS Diclofenac
The same association (BioDNA Cellular Marine Complex and vitamins B and E) was tested against Diclofenac (an anti-inflammatory, non-steroid) on a group of 67 persons affected by arthrosis (inflammatory joint pain) with average disability of the knees and hips.

With approximately 42 days of treatment, the pain was reduced by 39% with BioDNA Cellular Marine Complex has chondrostimulate (chronic arthritis) activity (versus 35% with Diclofenac), and the degree of impotence was reduced by 16.1% with BioDNA Cellular Marine Complex (versus 26.1% with Diclofenac).
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Clinical Study 3a: Celergen BioDNA Cellular Marine Complex Is Effective For Asthenia (Loss Of Strength And Energy)
In an open clinical study where 44 asthenic (loss of strength and energy) adults (having no less than 15 of the 60 asthenia (loss of strength and energy) symptoms present) were compared to 32 normal adults (having less than 15 of the 60 asthenia symptoms present).

The consumption of BioDNA Cellular Marine Complex by the asthenic patients reduced 62.7% of the physical asthenic symptoms and 40% of the mental asthenic symptoms.

The scores observed in the treated asthenic patients directly approached those patients seen as normal.

Almost all the asthenia symptoms (58 to 60) were improved and many of the most debilitating symptoms were particularly diminished. The action on asthenia by BioDNA Cellular Marine Complex globally is positive in 52.4% of the cases.

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Clinical Study 3b: Effect Of Celergen BioDNA Cellular Marine Complex On Physical And Mental Symptoms
In a multi-centered study, a group of 688 adults (445 woman and 243 men) showed spontaneous asthenia (loss of strength and energy) during the interrogation. Those who were isolated or associated with a non-evolutionary benign organic pathology, the treatment by BioDNA Cellular Marine Complex (800mg/day for 15 days) permitted a reduction of the Behavior Rating Scale (61 criteria) of 64.5% for physical asthenia and 57.0% for mental asthenia. The amelioration was more intensely marked, than were the more severe symptoms. The global efficacy of the treatment was well evaluated by researchers in 79.1% of the cases.

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Clinical Study 3c: Effect Of Celergen BioDNA Cellular Marine Complex On Physical Fatigue
In another open study, where it was noted that patient did not receive another anti-asthenia treatment (70% of the cases), of 6876 patient treated for 15 days by an association of BioDNA Cellular Marine Complex (400mg/day) and ascorbic acid (1g/day), fatigue at night was improved ( a reduction of more than 50% of the intense symptoms) in 82.5 % of the cases, fatigue in the morning by 82.9% of the cases, difficulty concentrating in 76.9% of the cases, trouble sleeping in 75% of the cases, and trouble with appetite in 80% of the cases.

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Clinical Study 3d: Effect Of Celergen BioDNA Cellular Marine Complex On Elderly People
Finally in an open clinical trial of 24 persons of more than 50 years of age with asthenia (loss of strength and energy) of which 16 had anorexia and 8 were chronic alcoholics, the taking of BioDNA Cellular Marine Complex (800 mg/day for 1 month) had improved the patients general state in 70% of the cases and their mental state in 63% of the cases.

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Clinical Study 4: Celergen BioDNA Cellular Marine Complex Accelerates The Consolidation Of Dental Joints And Treatment Of Parodonties (Gum)
On a group of 108 patients affected by periodontal pathology, the administration of BioDNA Cellular Marine Complex (1600 mg/day for 3 months) reduced the index of dental mobility to a high of 45.7% and a low of 22.5%. fifty six percent (56%) of patients treated with BioDNA Cellular Marine Complex have found that the treatment was a success against only 7.5% who were only treated with a traditional local method.

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Clinical Study 5: Celergen BioDNA Cellular Marine Complex Has Regenerative Action On Intellectual Development
In regard to psychomotor and biometrics of subjects with mental defects. In the course of a double blind study of 256 children between the ages of 6 and 21 with an average to profound mental defects; and who exhibited exogenous defects with an intellectual quotient (IQ) superior to 40 and a real age understanding of between 8 and 14 years, the children had benefited by gaining mental age after taking BioDNA Cellular Marine Complex (200 to 600 mg/day) for 3 months.

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Clinical Study 6: Celergen BioDNA Cellular Marine Complex Possesses A Radiation Protective Power
In an experiment at Sloan Kettering Cancer Facility in New York rats given mortal doses of radiation, were seen to survive when given “injections” of BioDNA Cellular Marine Complex prior to irradiation. The protection and function of the BioDNA Cellular Marine Complex administered was directly proportional to the degree of Polymerization.

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Clinical Study 7:
Celergen BioDNA Cellular Marine Complex Has a Regenerative Action VS the Cicatriciels (Healing of) Process
In effect, in mice after the realization of experimental wounds, the administration of
BioDNA Cellular Marine Complex accelerated the cicatrisation (healing of) by augmenting the proliferative activity
and the number of polypoid epidermal cells. In rats one hour after the administration of 325 mg/kg of aspirin,
the taking of BioDNA Cellular Marine Complex (10 to 50 mg.kg per os) prevented the apparition of gastric ulcers from aspirin.

Peptide E Collagen


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Peptide E Collagen comprises the highest premium grade quality collagen and elastin peptides from France and has been proven to reinforce skin hydration and elasticity.

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Peptide E Collagen polypeptides have a low molecular mass that makes it soluble in aqueous phase and fully digestible.
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Peptide E Collagen Clinical Studies

Clinical Study 1: Reduction Of Lines And Wrinkles
Made up of the 2 main components of outer skin layers, collagen and elastin, Peptide E Collagen is easily absorbed, lifting and toning slack areas, improving hydration and skin thickness while also reducing lines, wrinkles and roughness.

This figure shows the effect of 2 grams/day of Peptide E Collagen given orally for 28 days on forearm wrinkles and crow’s feet in 43 healthy female volunteers, aged 40-55 years.

At 28 days, 71% of subjects in the Peptide E Collagen group showed a significant decrease in the number of deep wrinkles. The average deep wrinkle reduction was equal to 19%. On the other hand, the control group showed further damage to their skin in the same period with a significant increase in deep wrinkles by 28% in 82% of subjects.

In other words, Peptide E Collagen rebuilds outer skin layers from the inside out and make your skin toned, supple and well hydrated while also reducing lines, wrinkles and roughness.

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Clinical Study 2:
Reduction In Swollen Joints In Rheumatoid Arthritis
Rheumatoid arthritis is an autoimmune inflammatory disease in which immune T cells react to type II collagen, damaging synovial membrane in the joint. The membrane slowly becomes thicker, destroying cartilage and other joint structures.

In a clinical trial conducted in 1993, hydrolyzed collagen was shown to reduce the number of swollen and tender joints in patients with severe rheumatoid arthritis. Hydrolyzed collagen is easily digested and absorbed by the body. This, along with its ability to accumulate in cartilage, makes Peptide E Collagen a powerful ingredient for alleviating the symptoms of rheumatoid arthritis.

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Hydro MN Peptide


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Hydro MN Peptide

Peptide M is a marine cartilage extract. It contains hydrolyzed proteins (mainly COLLAGEN ll) and polysaccharides (35 to 40% chondroitin sulphate). Its active contents increase with purification.

Peptide N has the Glycemic Index reducing property, and, thus, is a natural mean to fight against the increasing number of overweight people and health disorders that are linked with obesity.
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Hydro MN Peptide Clinical Studies

Clinical Study 1:
Effect of Peptide N on Blood Glucose Levels After Meals
Peptide N, one of Celergen’s ingredients is a marine protein hydrolysate proven to reduce the dietary glycemic index or GI. Peptide N has been shown to prevent unhealthy body fat accumulation, which aids in maintaining a healthy body weight and reducing the risk of obesity, whilst alleviating symptoms of type II diabetes.

Glucose that enters the blood from food is used for energy production in the body’s cells, while excess glucose is transformed into fat and stored for later use. Over time this constant storage of fat leads to obesity. Second, frequent sharp, prolonged peaks of blood glucose and insulin (from high GI foods) are known to increase risk for insulin resistance and type II diabetes. On the other hand, a gradual release of blood glucose (from low GI foods) does not affect this risk and also delays hunger pangs.

This figure shows the results of a study evaluating the effects of 4 different proteins – Peptide N, fish fillet, casein milk protein and soy protein isolate – on blood glucose levels in 17 female volunteers (aged 32-64 years). Each volunteer consumed these proteins in random order, always as part of composite meals of similar macronutrient composition with a 1-week gap between each meal.

Blood samples were taken from each volunteer to assess levels of glucose, insulin and other biomarkers in the fasting state and 7 times after each meal, for up to 240 minutes.

This study found that Peptide N supplementation resulted in a significantly blunted blood glucose response than with fish fillet protein or soy protein isolate, lowering the risk of obesity and alleviating symptoms of type II diabetes. In other clinical studies, Peptide N has also been shown to reduce the appetite and promote satiety via its actions on metabolic hormones.

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Clinical Study 2: Effective For Treatment Of Photoaging by Peptide M
Exposure to sun and other sources of UV-radiation are the key factors in causing
premature skin aging that lead to problems such as wrinkles, roughness, laxity, mottled pigmentation, etc.

Numerous clinical studies have shown how oral marine polysaccharides supplements could be helpful
in the dermal thickness, skin wrinkling, skin colour and viscoelasticity with considerable improvement.